Abstract. The therapeutic efficiency and safety of the proteolytic enzyme bromelaine obtained from pineapple. (Bromelain-POS®, Ursapharm GmbH. Ananas comosus, Ananas sativus, Ananase®, Bromelain-POS, bromeline ( pleural), Bromelainum, Bromeliaceae (family), Bromelin, Bromelins, Debridase. Ursapharm Arzneimittel Gmbh provides wide range of pharmaceutical products which includes bromelain-pos.

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My Account Contact Us. Background Bromelain is a sulfur-containing proteolytic digestive enzyme that is extracted from the stem and the fruit of the pineapple plant Ananas bromelaiinfamily Bromeliaceae. When taken with meals, bromelain is believed to assist in the digestion of proteins.

When taken on an empty stomach, it is believed to act medicinally as an anti-inflammatory agent. Evidence Table These uses have been tested in humans or animals. Safety and effectiveness have not always been proven.


Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. Studies report mixed results, although overall bromelain appears to be beneficial for reducing swelling and improving breathing.

Better studies are needed before a strong recommendation can be made. B A bromelain-derived debriding agent, Debridase, has been studied on deep second degree and third degree burns with positive results.

Further results are needed to confirm these results. C There is not enough information to recommend for or against the use of bromelain in the treatment of cancer, either alone or in addition to other therapies.

Bromelain (Ananas comosus, Ananas sativus) – Better Life Whole Foods

C Bromelain is an enzyme with the ability to digest proteins. However, there is little reliable scientific research on whether bromelain is helpful as a digestive aid. Better study is needed before a firm conclusion can be made. C Several preliminary studies suggest that when taken by mouth, bromelain may reduce inflammation or pain caused by inflammation. Better quality studies are needed to confirm these results. C Bromelain may reduce mild acute knee pain in a dose-dependent manner.

C The effects of bromelain on muscle soreness following intense exercise are unclear. C There is not enough information to recommend for or against the use of bromelain as a nutritional supplement. C There is conflicting evidence on the effectiveness of bromelain to treat osteoarthritis.

Further well-designed clinical trials of bromelain alone are needed to confirm these results. C Bromelain may help treat skin rash.

This treatment may be effective because bromelain has been shown to decrease inflammation, regulate the immune system, and have antiviral effects.

C There is not enough information to recommend for or against the use of bromelain in rheumatoid arthritis RA. C There is not pps information to recommend for or against the use of bromelain in the treatment of steatorrhea. C There is not enough information to recommend for or against the use of bromelain in urinary tract infections. Strong brokelain evidence for this use B: Good scientific evidence for this use C: Unclear scientific evidence for this use D: Fair scientific evidence bromepain this use it may not work F: They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven.


There may be other proposed uses that are not listed below. Dosing Adults 18 years bdomelain older A variety of doses have been used and studied. The German expert panel, the Commission E, has recommended 80 to milligrams to FIP brimelain taken two to three times per day. Some authors recommend to 1, milligrams of bromelain to be taken three times daily, and many manufacturers sell products standardized to 2, GDU in milligram tablets.

Effects of bromelain may occur at lower doses, and treatment may be started at a low dose and increased as needed.

Children younger than 18 years There is not enough scientific research to recommend safe use of bromelain in children. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary.

You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before bromdlain a new therapy. Consult a healthcare provider immediately if you experience side effects. Allergies There are multiple reports of allergic and asthmatic reactions to bromelain products, including throat swelling and difficulty breathing.

Side Effects and Warnings Few serious side effects have been reported with the use of bromelain.

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The most common side effects reported are stomach upset and diarrhea. Other reported reactions include increased heart rate, nausea, vomiting, irritation of mucus membranes, and menstrual problems. In theory, bromelain may increase the risk of bleeding.

Caution is advised in people who have bleeding disorders or who are taking drugs that increase the risk of bleeding. Dosing adjustments may be necessary. Bromelain should be used with caution in people with stomach ulcers, active bleeding, a history of bleeding, taking medications that thin the blood, or prior to some dental or surgical procedures. Bromelain may increase heart rate at higher doses and should be used cautiously in people with heart disease.

Some experts warn against bromelain use by people with liver or kidney disease, although there is limited scientific information in these areas.

Pregnancy and Breastfeeding Bromelain is not recommended during pregnancy or breastfeeding, as little safety information is available. Bromelain may cause abnormal uterine bleeding. Interactions Interactions with Drugs In theory, bromelain may increase the risk of bleeding when taken with drugs that increase the risk of bleeding.

Human studies suggest that bromelain may increase the absorption of some antibiotics, notably amoxicillin and tetracycline, and increase the levels of these drugs in the body.

Bromelain may increase the actions of the chemotherapy anti-cancer drugs 5-fluorouracil and vincristine, although reliable scientific research in this area is lacking.

Some experts suggest that bromelain may cause drowsiness or sedation and may increase the amount of drowsiness caused by some drugs. Caution is advised while driving or operating machinery.

Bromelain may also interact with heartbeat ps medications, magnesium, and nicotine. Interactions with Herbs and Dietary Supplements In theory, bromelain may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding.


Multiple cases of bleeding have been reported with the use of Ginkgo bilobaand fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this ops not been proven in most cases.

Bromelain broelain the enzyme trypsin are suggested to have stronger anti-inflammatory effects when combined, based on preliminary animal research. It has been suggested that zinc might block the effects of bromelain in the body while magnesium may increase the effects, although scientific bormelain in these areas is lacking. Bromelain may also interact with bromelaon and supplements that effect the heart, antibacterials, soy, sedatives, and tobacco. Attribution This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration www.

Double-blind cross-over trial of an enzyme preparation in pancreatic steatorrhoea. J Assoc Physicians India ;29 3: Bromelain as an adjunctive treatment for moderate-to-severe poe of the knee: Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany.

In Vivo ;19 2: Five years of clinical experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clinical Medicine ;74 6: A double-blind trial of bromelains as an adjunct to bormelain plastic repair operations.

J Obstet Gynaecol Br Commonw ;77 4: The effect of bromelain therapy on episiotomy wounds–a double blind controlled clinical trial. J Obstet Gynaecol Br Commonw ;79 Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of bromelaib hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs.

Clin Exp Rheumatol Jan-Feb;24 1: Role of bromelain in the treatment of patients with pityriasis lichenoides chronica. J Dermatolog Treat ;18 4: Med Prax ;62 The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method.

Bromelai Obstet Gynaecol Jpn ;19 3: Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Oral bromelains as adjuncts in the treatment of acute thrombophlebitis. Adjunctive use of bromelains in sinusitis: Eye Ear Nose Throat Mon ;46 Weiss S, Scherrer M.

Schweiz Rundsch Med Prax ;61 Information is based on review of scientific research data, historical practice patterns, and clinical experience.

Bromelain-POS –

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