Blinded MRI analysis demonstrated that BST-CarGel®-treated patients showed a significantly greater treatment effect for lesion filling (P = ) over 5 years. BST-CarGel is an advanced bioscaffold technology for enhancing cartilage regeneration. BST-CarGel was developed to stabilize the blood clot in the cartilage lesion by dispersing a soluble and adhesive polymer scaffold containing chitosan.
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This multi-centre randomized, controlled trial will assess the impact of BST-CarGel scaffold with microfracture versus microfracture alone on short and long term clinical benefit in patients with cartilage lesions of the femoral condyle requiring operative management. Related Searches Intramedullary nail Electrosurgical device Interference screw Bone support Acetabular prosthesis Linear stapler Arthrodesis plate Femoral prosthesis Tonsillectomy electrode Tibia compression plate Medical balloon catheter Wound therapy unit Cemented knee prosthesis Femoral head prosthetic Adenoidectomy electrode Anterolateral compression plate Dilatation catheter Arthrodesis screw Unicompartmental knee prosthesis Knee prosthetic.
None of the characteristics bsst found to be significant covariates leading to bias during sensitivity analyses, despite reports that clinical outcomes after microfracture are age dependent.
J Orthop Sports Phys Ther. Which measures symptoms and disabilities most important to postoperative articular cartilage repair patients? The adverse effect of elevated body mass index on outcome after autologous chondrocyte implantation. Limitations and sources of bias in clinical knee cartilage research. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: Baseline demographic characteristics of the 80 patients were similar in the two treatment groups, including age, race, gender, BMI, smoking habits, and activity levels.
Customized high—spatial resolution pulse sequences specific for morphological or T2 relaxation time analyses of regions of interest were used.
Check availability of results on the Clinicaltrials. Longitudinal analysis of repeated measures using general estimating equations GEE for the quantity and quality of repair cartilage over 5 years posttreatment. Thus, with clinical benefit being shown at acceptable levels for most cartilage repair therapies 33346768 and for significantly long follow-up periods, superiority of one therapy or technique falls to the structure of the replaced or regenerated cartilage within the lesion, such as was found in this trial.
Correlation between magnetic resonance imaging and clinical outcomes after cartilage repair surgery in the knee: Open the catalog to page 9. Cargeo of full thickness chondral lesions of the knee with microfracture in a group of athletes.
First, the study was not powered for a clinical benefit endpoint. Leave undisturbed for a minimum of 10 minutes. P values of less than 0. Consequently, the correlation between repair tissue structure and clinical outcomes has cwrgel elusive. J Bone Joint Surg Am.
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Characteristics of the immediate postarthroscopic blood clot formation in the knee joint. For morphological analyses of cartilage, cartilage lesions and bone, both coronal and sagittal 3-dimensional fat-suppressed spoiled gradient echo SPGRand sagittal 3-dimensional gradient echo GRE sequences were used.
The microfracture technique for the treatment of articular cartilage lesions in the knee. Collagen of articular cartilage.
Several studies have reported relationships between structural assessments and cadgel clinical outcomes, but these studies suffer from small sample sizes, statistical rigor, and subjective scoring of both the structural and the clinical components. J Bone Joint Surg Am. Furthermore, the trial outcomes reported here at acrgel years are likely conservative estimates since 2 negative prognosticators, higher BMIs and larger lesions, were found in the enrolled patients compared with those who did not enroll in the extension study, although neither were found to be significant statistical covariates.
The extension study protocol https: Shive1 William D.
Findings at five years. Further details and illustrations in Stanish et al. Open in a separate window. Introduction The search for a solution to problematic articular cartilage lesions continues despite decades of orthopedic experience in the knee. Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage bbst of the knee? If you know someone who would be interested in this clinical trials, enter their email address.
The equivalent clinical improvement between groups was an expected finding for 2 predictable reasons. Mean T2 is derived from the entire repair cartilage volume.
Trial Detail – UK Clinical Trial Gateway
This is in the inclusion criteria above. We do not have evidence based methods for the treatment of cartilage defects in the knee. Structural characteristics of the collagen network in human normal, degraded and repair articular cartilages observed in polarized light and scanning electron microscopies. The response of articular cartilage to mechanical injury.
Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger?
The extension study suffered patient loss to follow-up at all planned time points due to several factors, including extremely protracted enrolment periods for both the initial 12 month trial and the extension study, compounded by financial bankruptcy of the original trial sponsor BioSyntech Canada Inc. The advanced bioscaffold technology for enhancing cartilage regeneration A minimally invasive one-step cartilage regeneration system Suited for most cartilage lesion cases Greater quantity and better quality of tissue compared to Microfracture alone The highest standard in cartilage regeneration randomized clinical trials.
BST-CarGel ® – Smith & Nephew – PDF Catalogs | Technical Documentation
Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. Shigemasa Y, Minami S. The trial was cxrgel since the independent third party carrying out the analyses of primary endpoints was unaware of patient treatment.
Caargel of Conflicting Interests: Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial.
T2 mapping in the knee after microfracture at 3.
Knee Surg Sports Traumatol Arthrosc. B Repair tissue T2 relaxation times: Safety was assessed through recording of all adverse events AEs up to 5 years posttreatment.