Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.
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MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al. From oral biopsies submitted during period between and ,40 0. The three-level grading mucoepidemoide commonly used by mucoepidermoidee for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Mucoepidermoid carcinoma of minor salivary glands: Further studies in order to clarify this point are warranted. The broad age range observed in our series supports that reported in literature.
MEC than that from intercalated duct. Mucodpidermoide palate was the most commonly affected site, with 21 cases Complete resection was defined as a histological report of negative margins of more than 10 mm.
Mucoepidermoid carcinoma of minor salivary glands: Although MEC has been described as a radioresistant glandulax, postoperative radiotherapy has been associated with decreased recurrence in some reports. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival.
Growth Factors, 24 2: Most of the studies show that the palate is the most common site of ocurrence Lopes et al. Its intracellular component mucoepiddrmoide a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al.
Oral Oncol, 41 1: Otolaryngol Head Neck Surg. This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis glanudlas head and neck mucoepidermoid carcinomas.
Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site. Clinical information about age, gender, and site were obtained from the biopsy records.
However, its prognostic value should be validated with clinical studies and survival analyses. The DFS was calculated as the time interval between the date of first treatment and the date of local disease recurrence or last information for censored observations when the patient was known to be disease-free.
Carcinoma ex pleomorphic adenoma of the salivary gland: Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes. Clinicopathologic and mucoepidrrmoide study of intraoral mucoepidermoid carcinoma.
We suppose that reasons for this contradictory mucoepidermoise are associated with the immunohistochemistry technique, in special with the primary antibody employed and with the subjective interpretation and semiquantitative nature of the results. However, in the study of Lopes et al.
However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. The majority of MECs 27 cases were classified as low grade of malignancy. Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.
High grade tumors, on the other hand, seem to arise more often muclepidermoide major salivary glands Kokemueller et al. This overexpression may be due to the process envolving histogenesis and celular differentiation. Data regarding the positivity for c-erbB-2 on salivary gland tumors are very variable.
Muc4 and erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma.
Few papers evaluating only one type of oral salivary gland tumors are available. Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al.
HER2 expression in salivary gland carcinomas: University of Sao Paulo, Brazil. English Copyright of International Journal of Morphology is the property of Sociedad Chilena de Anatomia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission.