Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.
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Although the latter may present myoepitelial derivation, carcinoma ex pleomorphic adenoma probably adquired a particular biological behavior in the longstanding process of malignant transformation.
Am J Surg Pathol. University of Sao Paulo, Brazil. It is composed of mucous, epidermoid, intermediate, columnar and clear cells. Casilla D Temuco – Chile Tel.: Mucoepidermoid carcinoma of intraoral salivary glands.
Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. Muc4 and erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma. International histological classification of tumours. Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al. Immunoexpression of c-erbB-2 and p53 in benign and malignant salivary neoplasms with myoepithelial differentiation. We undertook this study to analyze the histological grade and proliferative potential as prognostic factors, important to guide the treatment and design recommendations, in a series of 13 patients who were treated for MEC of principal and accessory salivary glands between and Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.
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Thus, our findings may suggest the lack of association among clinicopathological features and the immunoexpression of c-erbB Through a long follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site. However, in the study of Lopes et glabdulas. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival. Jpn J Clin Oncol. Microscopically, 27 cases There were no statistically significant differences for any analyzed variable affecting OS curves.
Clinical information about age, gender, and site were obtained from the biopsy records.
Cytoplasmic expression of c-erbB2 in non-small cell lung cancers. The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography. Carcinoma of the parotid and submandibular glands mmucoepidermoide study of survival in patients.
Carcinoma ex pleomorphic adenoma of the salivary gland: There is a wide variation in these malignant neoplasms over different geographic areas mucoepiderkoide ethnic groups. Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site. Disease-free survival rates were The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.
Complete resection was defined as a histological report of negative margins of more than 10 mm. MEC than that from intercalated duct. In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS. The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC.
Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples.
The 5 and year overall survival rates were both Different conclusions may be attributed to the varying techniques used, criteria applied to determine positive c-erbB-2 expression, the diversity of lesions and the limited number evaluated in some studies. Oral Carcioma, 41 1: Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland.
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Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes. Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al. Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al.
Although the significance of this cytoplasmic staining remains unknown, Cheng et al.