Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Penecillin to prevent leg cellulitis NEJM ; Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs.

The primary outcome was the time to a first recurrence. We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland. Bilateral cellulitis is nenm.

Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection. Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo cellulotis 12 months were dispensed by a central pharmacy.


Statins can interact with some antibiotics and increase the risk of rhabdomyolysis. Are they suitable for compression?

Penicillin to prevent recurrent leg cellulitis.

In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped. N Engl J Med. Participants were followed for up to 3 years. Leg Ulcers and recurrent cellulitis.

Penicillin to prevent recurrent leg cellulitis.

We compared prophylactic low-dose penicillin with placebo for the prevention celulitis recurrent cellulitis. Refer for specialist opinion if severe infection Is it cellulitis? Is it chronic changes of venous stasis and chronic ulceration? Antibiotics do not improve healing unless active infection.

Leg Ulcers and recurrent cellulitis –

Review antibiotics after culture results. Please refer to our Drug Interactions Table for further information. Skip to main content. Prophalactic antibiotics for the prevention ccellulitis cellulitis erysipelas of the leg: Many antibiotics increase the risk of bleeding with anticoagulants.


Baseline characteristics were similar in the two groups. Amiodarone and drugs which prolong the QT interval can interact with many antibiotics.

Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. Colonisation is likely in leg ulcers. The median cellulitix to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group.

Comment in N Engl J Med. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only.

Doses are oral and cellulitiis adults unless otherwise stated. A total of patients were recruited.