CLASSIFICATION OF ANTIHYPERLIPIDEMIC DRUGS PDF

Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Chapter 18 Antihyperlipidemic Agents LEARNING OBJECTIVES Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics.

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Ezetimibe has no clinically meaningful effect on the plasma concentrations of the fat-soluble vitamins A, D, and E. At high doses, cholestyramine and colestipol impair the absorption of the fat-soluble vitamins A, D, E, and K.

Anti Hyperlipidemic Drugs |authorSTREAM

Colesevelam has fewer gastrointestinal side effects and not Impaired absorptions PowerPoint Presentation: Start Free Trial No credit card required. Diabetes Mellitus with one of the primary hyperlipidaemias. Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics based on the structure and mode of action Define HMG-CoA and its role in hyperlipidemia Define the pharmacophoric requirements of the statin class of antihyperlipidemics Describe some antihyperlipidemics obtained from fermentation process Describe the cholesterol biosynthetic pathway and its significance Define PPAR?

Presentation Description No description available. Antihyperlipidemic agents promote reduction of lipid levels in the blood. They may differ in both their impact on the cholesterol profile and adverse effects.

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Antihyperlipidemic agents

Familial mixed hypertriglyceridemia V: Lipid disorders Disorders of lipid metabolism are manifest by elevation of the plasma concentrations of the flassification lipid and lipoprotein fractions total and LDL cholesterol, VLDL, triglycerides, chylomicrons and they result in cardiovascular disease and atherosclerosis deposition of fats at walls of arteries, forming plaque.

Alpha- tocopherol acetate vitamin E Has no effect on lipid levels but is a powerful antioxidant.

Their half-lives range from 1. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Lipid-lowering agent

Views Read Edit View history. Because these drugs increase biliary cholesterol excretion, there is a predisposition to the formation of gallstones.

Anti- hyperlipidemic drugs are mainly classified into 5 types: They should not be used in children or teenagers. Adverse effect of statins PowerPoint Presentation: In addition, it is the most potent antihyperlipidemic agent for raising plasma HDL levels, which is the most common indication for its clinical use.

Chapter Antihyperlipidemic Agents – Medicinal Chemistry, 2nd Edition [Book]

Subscribe to receive email notifications whenever new articles are published. Hyperuricemia and gout Niacin inhibits tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity. Describe some new drug classes useful in the treatment of hyperlipidemia and atherosclerosis.

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Types of Antihyperlipidemic agents Please refer to the drug classes listed below for further information. Hypolipidemic agentsor antihyperlipidemic agentsare clsasification diverse group of pharmaceuticals that are used in the treatment of high levels of fats lipidssuch as cholesterol, in the blood hyperlipidemia. Adveres effect of fibric acid derivatives Gastrointestinal effects Lithiasis: ColesevelamColestipolCholestyramine Nicotinic acid: Elzonris Elzonris tagraxofusp-erzs is a CDdirected cytotoxin for the treatment of You do not have the permission to view this presentation.

Plasma creatine kinase levels should be determined regularly. Contraindication Where hepatic or renal function is severely impaired but gemfibrozil has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women. AtorvastatinFluvastatinLovastatinPravastatinSimvastatin. Orally given but neither absorbed nor metabolically altered by intestine, totally excreted in feces.

Thus, it is important to evaluate INR Contraindications: This page was last edited on 23 Februaryat Clinically, the choice of an agent will depend on the patient’s cholesterol profilecardiovascular riskand the liver and kidney functions of classifiction patient, evaluated against the balancing of risks and benefits of the medications.